Building upon the long history of Career and Technical Education (CTE), we will explore the latest innovations in models and approaches that integrate career-connected coursework, training, and work-based learning experiences that enable high school students to graduate with a credential of labor-market value and launch careers that provide economic mobility. We will learn from past efforts in CTE and leading-edge solutions for redesigning the high school to postsecondary and career transition space, including modern youth apprenticeship programs, national scale enterprises, enabling technologies, and non-degree credentials. Our panel of experts will discuss how K-12, postsecondary, and employers can effectively collaborate to reshape the possibilities for how students are prepared for career pathways during high school.